Study of Etanercept in the Treatment of Psoriasis in Adult Subjects

Original Study ID : 20040216

NCT ID : NCT00121615

Brief Title : Study of Etanercept in the Treatment of Psoriasis in Adult Subjects

Official Title : An Open-Label, Long-Term Extension Study to Assess the Safety and Efficacy of Etanercept in the Treatment of Psoriasis in Adult Subjects

Brief Summary :

The objective of the study is to describe the safety, tolerability, and efficacy of the long-term administration of etanercept in adults with psoriasis who have completed etanercept psoriasis study 20030115 or 20030117, in Canada, and are continuing in a long-term extension. Subjects from the 20030115 study will be followed for 24 months which began in Oct. 2004. Subjects in the 20030117 study will be followed for 12 months which began in mid 2005.

Source : Amgen

Overall Status : Completed

Start Date : October 2004

Official Title : Phase 3

Phase : Interventional

Study Design : Treatment, Non-Randomized, Open Label, Single Group Assignment, Safety/Efficacy Study

Enrollment : 391

Verification Date : March 2009

First Received Date : June 30, 2005

Trial Eligibility

Criteria :
Inclusion Criteria: - Subjects who completed study 20030115 or 20030117 qualify to enroll
into this study (provided that they meet all inclusion/exclusion criteria). -
Heterosexually active men and women of child-bearing potential must agree to use a
medically acceptable form of contraception throughout the study. - Subject or designee must
have the ability to self-inject investigational product. - Subject must be capable of
understanding and giving written voluntary informed consent. - Negative serum pregnancy
test less than or equal to 14 days prior to the first dose of investigational product in
all female subjects (except those surgically sterile or at least 5 years postmenopausal)
Exclusion Criteria: - Active guttate, erythrodermic, or pustular psoriasis at the time of
the baseline visit - Any adverse event or infection at the time of the baseline visit or at
any time during the previous etanercept psoriasis study which, in the opinion of Amgen or
the Investigator, would preclude participation in the study - Presence of a serious
infection less than or equal to 30 days prior to the baseline visit - Evidence of skin
conditions at the baseline visit (e.g., eczema) that would interfere with evaluations of
the effect of investigational product on psoriasis - Previous receipt of anti-TNF agent(s)
other than etanercept - Receipt of any investigational product(s), other than etanercept,
less than or equal to 30 days prior to first dose of investigational product in this study
- Receipt of anti-CD4 or diphtheria IL-2 fusion protein less than or equal to 24 weeks
prior to first dose of investigational product in this study - Psoralen and ultraviolet A
(PUVA) light therapy less than or equal to 14 days prior to first dose of investigational
product in this study - Ultraviolet A (UVA) light therapy less than or equal to 14 days
prior to first dose of investigational product in this study - Ultraviolet B (UVB) light
therapy less than or equal to 14 days prior to first dose of investigational product in
this study - Receipt of any other systemic psoriasis therapy or oral or parenteral
corticosteroids less than or equal to 14 days prior to first dose of investigational
product in this study - Pregnant or breast-feeding females - Significant concurrent medical
conditions prior to enrollment, including: uncontrolled hypertension (defined as systolic
blood pressure measurement of greater than 180 mm Hg or an untreated diastolic blood
pressure of greater than 110 mm Hg); myocardial infarction less than or equal to 52 weeks
prior to baseline visit; unstable angina pectoris; uncompensated congestive heart failure;
severe pulmonary disease requiring hospitalization or supplemental oxygen therapy;
diagnosis of multiple sclerosis or any other demyelinating disease; insulin-dependent
diabetes mellitus; history of cancer (other than in-situ cervical cancer or resected
cutaneous basal cell or squamous cell carcinoma) less than or equal to 5 years prior to
administration of first dose of investigational product; open cutaneous ulcers; known human
immunodeficiency virus (HIV), hepatitis B surface antigen (HbsAg) or hepatitis C virus
(HCV) positive; any condition that might cause this study to be detrimental to the subject,
in the judgment of the investigator.

Gender : Both

Minimum Age : 18 Years

Maximum Age : N/A

Healthy Volunteers : No

OutComes

Primary OutComes

Measure : Subject incidence of serious adverse events, including serious infections, non-melanoma skin cancer, and all malignancies, and all adverse events.

Secondary OutComes

Measure : Longitudinal changes from baseline for the Physician and Patient Global Assessments and DLQI

Interventions

Type : Drug

Name : etanercept

Clinical Trial Name - Study of Etanercept in the Treatment of Psoriasis in Adult Subjects